In October 2019, Andrew Anzalone, a postdoctoral fellow in David Liu's lab, and colleagues unveiled a groundbreaking innovation in genetic engineering known as Prime Editing, in a publication featured in Nature. This development represents a significant stride forward in the realm of genetic manipulation, offering a highly precise and versatile method that addresses several limitations encountered with conventional CRISPR-Cas9 systems. Let's delve into the essence of Prime Editing, exploring its functionality and several advantages.

As we navigate through the constantly evolving landscape of biotechnology, we want to take a moment to share some significant milestones and exciting updates from our journey at PixelBiosciences. Reflecting on the past year, it has been a period of transformation and growth, leading us to a pivotal point in our journey. Today, we're thrilled to announce that after a thoughtful restructuring process, we have emerged with a new identity: PixelBiosciences GmbH.

In the realm of genetic research, DNA FISH has long been a stalwart technique for unraveling chromosomal mysteries, shedding light on chromatin organization, and diagnosing clinical abnormalities. However, its reliance on heat denaturation and the need for lengthy target regions have posed significant obstacles, particularly when dissecting fine chromatin structures below 10 kilobases (kb), such as those introduced by exogenous genes during cell and gene therapy.

Do you have a set of genes whose expression needs to be validated after RNA sequencing or microarray? Do you want to visualize multiple cell types in a tumor microenvironment? NovaFISH is here to help.

NovaFISH is a new kind of single-molecule FISH (smFISH) technique that enables you to quantify gene expression with spatial information and digital quantification. Due to the intrinsic low signal of smFISH (dozens of fluorophores on each stained RNA dot), we have several suggestions on the image acquisition of smFISH samples, including NovaFISH, to get high-quality images for accurate and reliable NovaFISH quantification.

Over the past few decades, advancements in cultivation methods and the rapid development of new and advancing technologies has been the driving force behind the “-omics era” and has greatly enhanced the rate of discovery for a myriad of microorganisms. However, applications of microarray and Next Generation Sequencing (NGS) technologies typically are very limited in determining the relative abundances of individual targets and visualization of cells, which are features of which fluorescence in situ hybridization (FISH) excels. For that reason, scientists have frequently turned to FISH as an effective methodology for driving microbiome research around the world.