Among 67 children treated with Bluebird Bio's gene therapy for a rare neurological disease, seven have developed blood cancer so far, with one child unfortunately passing away.

The TnpB system is not only small in size but also possesses powerful gene-editing capabilities, bringing a new breakthrough to gene-editing technology.

PixelBiosciences GmbH Co., Ltd. is dedicated to the research and development of RNA synthesis. Recently, our company has achieved a remarkable breakthrough in the field of RNA synthesis, successfully synthesizing RNA molecules with a length of 300nt. This advancement not only demonstrates our leading position in technology but also brings new possibilities for biomedical research and applications.

Recently, David Liu's team has made another breakthrough in gene editing technology. The new system, eePASSIGE, can insert exogenous fragments up to 10kb in length, with an integration efficiency 16 times higher than previous systems.

PixelBiosciences GmbH Co., Ltd. has made progress in long-chain RNA synthesis, and successfully achieved the enzymatic synthesis of 200nt RNA.

In the realm of genome editing, precision is paramount. Scientists strive to achieve pinpoint accuracy when manipulating genetic material, whether for basic research or therapeutic applications. One of the key tools enabling this precision is the single-guide RNA (sgRNA). In this blog post, we'll explore various strategies for designing sgRNAs to facilitate precise genome editing.